Diagnostic Value of Combination of Collagen IV and CEA Test on Patients with Colorectal Cancer Liver Metastases

Abstract

Objective: To evaluate and analyze the diagnostic value and significance of the combination of collage IV and CEA test on patients with colorectal cancer liver metastases. Methods Taking 84 cases of patients with colorectal cancer liver metastases admitted by Traditional Chinese Medicine Hospital Dianjiang Chongqing as metastatic group, and other 67 cases of patients with non-metastatic colorectal cancer as non-metastatic group from February 2013 to March 2014. Medical history of hepatitis, cancer site, cancer differentiation status, CEA level, collagen IV level of patients in different groups have been compared and analyzed by multiple logistic regression. At the same time, the 3-year survival rate of patients with different CEA and collagen level in metastatic group as well as serum CA125 and CA19-9 between patients in different groups have been compared. Results Patients with an increase of CEA and collagen IV share respectively 64.29% (54/84) and 72.62% (61/84) in the metastatic group, which are higher than those in the non-metastatic group (32.84% (22/67) and 28.36%(19/67)) (P<0.05); according to the analysis of multiple logistic regression, CEA and collagen IV levels are risk factors for the development of colorectal cancer liver metastases; the 3-year survival rate of patients with an increase of CEA and collagen IV is lower than that of patients without CEA and collagen IV changes (P<0.05); serum CA125 and CA19-9 are higher of patients in the metastatic group than those in the non-metastatic group (P<0.05). Conclusion The combination of collagen IV and CEA test could effectively diagnose colorectal cancer liver metastases, which could be serving as a clinical prognostic indicator. And determination of serum CA125 and CA19-9 could help with the diagnosis of colorectal cancer liver metastases, which should gain much attention.