Journal of Nursing

Exploration of Vancomycin Concentrations in Cerebrospinal Fluid and Plasma after Craniocerebral Surgery

Zhuo Li, Yaling Shi, Jiangping Lian, Xiaochuan Li, Yaning Zhu, Lu Cao


Patients who underwent cranial hematoma removal, extra-ventricular drainage, intracranial arteriovenous malformation resection, and other craniotomy procedures and were administered vancomycin were selected. Cerebrospinal fluid (CSF) and plasma specimens were collected simultaneously from patients at different time points using the random number method, and vancomycin concentrations in CSF and plasma were determined by enzyme amplification immunoassay. The ratio of vancomycin in CSF to plasma concentration was calculated, and the medical records were analyzed to initially investigate the relevant factors that can affect the drug concentration or blood-brain barrier. The mean plasma concentration of vancomycin was 11.87±8.5μg/mL, the CSF concentration was 2.42±1.34μg/mL, and the cerebral blood ratio was 0.28±0.21. This study suggests that the transmission rate of vancomycin did not increase significantly after craniocerebral surgery; due to individual differences, CSF and plasma concentrations vary greatly, and drug concentration monitoring is recommended.


Blood-Brain Barrier; Enzyme Amplification Immunoassay; Blood Drug Concentration; CSF Concentration

Full Text:



Wang DX, Wu Q, Tan X, et al. Meta-analysis of epidemiological investigation of intracranial infections after craniosynostosis[J]. West China Medicine.2013,10: 1530-1534.

Huang J, Bai J, Zhao ZG. Overview of blood-brain barrier permeability of antibacterial drugs[J]. Drug Evaluation,2012, 35:32-36.

Liu C, Bayer A, Cosgrove SE, et al. Clincal practice-guide-lines by the Infectious Diseases Socitey of America for the treatment of methicillin- resistant Staphylococcus aureus infections in adults and children: executive summary [J]. Clin Infect Dis,2011, 52(3):285-292.

Chinese expert consensus on the clinical application of vancomycin (2011 edition) [J]. Chinese Journal of New Drugs and Clinics,2011,08:561-572.

Chen Xiandong, Cai Jianyong, Ba Huajun, Chen Maohua, Dai Junman, Sun Jun. Efficacy of combined intravenous and intrathecal application of vancomycin in the treatment of intracranial infection in patients after craniotomy[J]. Chinese Journal of Hospital Infection, 2016, 07: 1569-1571.

Cai Y, Zhang X, Quan J et al. Determination of vancomycin cerebrospinal fluid penetration rate and analysis of related factors in patients with postoperative neurosurgical infection[J]. Chinese Journal of Hospital Infection,2016,24:5628-5631.



  • There are currently no refbacks.

Copyright (c) 2021 Zhuo Li, Yaling Shi, Jiangping Lian, Xiaochuan Li, Yaning Zhu, Lu Cao

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.