Journal of Nursing

Data mining based on tonifying kidney to treat vascular dementia prescription drug law

Yuanfeng Cui, Shuya Qin, Xiaoying Ma, Ling Li


Objective Combined with the theory of kidney brain interaction in traditional Chinese medicine, to discuss the medication rule of traditional Chinese medicine in treating vascular dementia of kidney deficiency type from the perspective of kidney. Methods The literatures on the treatment of vascular dementia with traditional Chinese medicine were retrieved from CNKI, Wanfang, VIP and other databases from 2012 to 2022. Excel 2019, SPSS Modeler 18.0, SPSS Statistics 25.0 were used for progressive flavor, warp transformation and efficacy analysis. Results A total of 131 literatures met the requirements, involving 149 traditional Chinese medicines. The drugs for tonifying deficiency, promoting blood circulation and removing blood stasis, eliminating phlegm and relieving cough and asthma were used more. The main sex tastes were warm and cold, Xin, sweet and bitter, which belonged to the three channels of liver, spleen and kidney. Association rules obtained 16 drug combinations and 4 new prescriptions were clustered. Conclusion Treating vascular dementia from kidney has profound theoretical source and remarkable clinical application effect, which can provide support for clinical prescription.


Vascular Dementia; Date Mining; Invigorating the Kidney; Medication Rule

Full Text:


Included Database


Deng C, Chen H, Meng Z, et al. Gastrodin and Vascular Dementia: Advances and Current Perspectives[J]. Evidence-Based Complementary and Alternative Medicine, 2022, 202:1-13.

Grysiewicz RA, Thomas K, Pandey DK. Epidemiology of Ischemic and Hemorrhagic Stroke: Incidence, Prevalence, Mortality, and Risk Factors[J]. Neurologic Clinics, 2008,26(4):871-895.

Cui YW, Zhang LC, Li Q, et al. Preliminary construction of "kidney brain system" in traditional Chinese Medicine [J]. Tianjin Traditional Chinese Medicine, 2015, 32(03):142-145.

Gao L, Hu YN. Treatment of vascular dementia from kidney [J]. Shanghai Journal of Traditional Chinese Medicine, 20,54(09):46-49.

National Pharmacopoeia Commission. Pharmacopoeia of the People's Republic of China: A [M]. Beijing: China Medical Science and Technology Press, 2020.

Zhong GS. Chinese Pharmacy (Ninth edition)[M]. Beijing: China Medical Science and Technology Press, 2016.

Wang YY, Ma F, Zhan YL. Interpretation of the Theory of Four Qi and Five Tastes of Traditional Chinese Medicine from the Jing Prescription for Treating nephropathy in "Treatise on Febrile Miscellaneous Diseases" [J]. Chinese Journal of Traditional Chinese Medicine, 2019,60(05):366-369.

Liu XY, Cui YD, Tian HL. Discussion on the relationship between the Theory of Four Qi and Five Tastes of Traditional Chinese Medicine and the reinforcing and purging of Zang-fu organs [J]. World of Traditional Chinese Medicine, 2021,16(01):121-124.

Li XQ, Zhao JQ, Tian YJ, et al. Research progress of Polygonum polygonum and Acorus mongolicum and their material basis and action mechanism of improving memory by drugs [J]. Chinese Journal of Experimental Formulae, 2019,25(03): 190-199.

Dong XG, Lu Manganese, Zhao Yun, et al. Efficacy and safety evaluation of Tonifying kidney, expelling phlegm and promoting blood circulation in the treatment of vascular dementia [J]. Journal of Traditional Chinese Medicine, 202, 37(02): 439-446.

Zhu KY, Fu Q, Xie HQ, et al. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae[J].j Sep Sci, 2010,33(23-24):3666-3674.

Hao J, Bai LY, Niu ZX, et al. Clinical effect of Yiqi Bushen Huoxue Huatan Prescription combined with conventional treatment on cognitive dysfunction of vascular dementia patients with kidney deficiency and blood stasis and phlegm turbidity block [J]. Chinese Patent Medicine, 202,44(03):789-793.

Zeng ZX, Zhang YL, Jin XL. Discussion on the core pathogenesis of vascular dementia from "kidney deficiency collaterals injury and pulp injury" [J]. Journal of Beijing University of Traditional Chinese Medicine, 2022,45(07):649-653.

Diao ZY, Wang F, Zhou SH, et al. Clinical evaluation of Dihuang Yin in the treatment of vascular dementia syndrome of kidney deficiency and phlegm stasis [J]. Chinese Journal of Experimental Formulas, 201,27(13):65-71.

Xu ZM, Wang M, Guo CY, et al. A review on the treatment of vascular cognitive impairment from kidney [J]. Beijing Journal of Traditional Chinese Medicine, 201, 40(10):1054-1057.



  • There are currently no refbacks.

Copyright (c) 2023 Yuanfeng Cui

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.