Resting Regional Cerebral Perfusion in Drug-Free First-Episode Schizophrenia with Arterial Spin Labeling Magnetic Resonance Imaging
Abstract
Objective This study aimed to explore the regional cerebral blood flow (rCBF) of first-episode schizophrenia (FES) by Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI) technique under resting condition. Method The rCBF was measured in 28 patients with FES and 28 healthy controls (HC). Result Patients with the FES showed significantly decreased rCBF. Conclusion Alteration of rCBF in FES patients observed in the current study suggested that the functional abnormalities of those areas were the features of early stage of the disease.
Keywords
Full Text:
PDFReferences
Lui, S., et al., Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging. Arch Gen Psychiatry, 2010. 67(8): p. 783-92.
Lui, S., et al., Association of cerebral deficits with clinical symptoms in antipsychotic-naive first-episode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. Am J Psychiatry, 2009. 166(2): p. 196-205.
Franck, N., et al., Cerebral blood flow changes associated with Schneiderian first-rank symptoms in schizophrenia. J Neuropsychiatry Clin Neurosci, 2002. 14(3): p. 277-82.
Min, S.K., et al., Positive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: a high-resolution SPECT study. Psychiatry Res, 1999. 90(3): p. 159-68.
Minoshima, S., et al., Anatomic standardization: linear scaling and nonlinear warping of functional brain images. J Nucl Med, 1994. 35(9): p. 1528-37.
DOI: http://dx.doi.org/10.18686/jn.v11i4.237
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Bingqiang Xu, Xia Zhe
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
