The Key Role of Hyperuricemia in Oxidative Stress, Inflammatory Response, and Endothelial Dysfunction
Abstract
Uric acid is the end product of purine metabolism in humans. A growing body of experimental and clinical evidence suggests that hyperuricemia has pathogenic effects in vivo such as inducing oxidative stress, promoting inflammatory responses, and causing endothelial dysfunction, and is involved in affecting systemic inflammatory responses and hemodynamics by a variety of mechanisms. This review will provide an overview of the role of hyperuricemia in oxidative stress, inflammatory response, and endothelial dysfunction.
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DOI: http://dx.doi.org/10.18686/jn.v12i1.241
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