Journal of Nursing

Research Progress on Peripheral Blood Lymphocyte Count and Cytokines for Sepsis

Xiaoying Fu, Faming He


Sepsis is a life-threatening organ dysfunction caused by infection leading to host immune dysregulation, and many studies display that it occurs high mortality and occupies a large of medical resources. Early diagnosis and timely treatment can significantly improve the prognosis of patients, and early anti-infective treatment is one of the most important treatment measures for serious infections, as it prevents the transition from pre-sepsis to sepsis and prevents direct death from infection.However, the current criterion, Sepsis-3, does not fully meet the definition of sepsis, and is not suitable for outpatient patients, so it is urgent to explore other ways to assist in early screening of sepsis. Starting from the pathophysiological mechanism of sepsis, this article summarizes the research progress on lymphocyte and cytokines for sepsis, and found that lymphocyte, IL-10 and IL-6 may be used as a joint indicator to diagnose sepsis and the prognosis so as to improve the prognosis of sepsis.


Sepsis; IL-6; IL-10; Lymphocytes; Early Diagnosis

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