Research Progress on Peripheral Blood Lymphocyte Count and Cytokines for Sepsis
Abstract
Sepsis is a life-threatening organ dysfunction caused by infection leading to host immune dysregulation, and many studies display that it occurs high mortality and occupies a large of medical resources. Early diagnosis and timely treatment can significantly improve the prognosis of patients, and early anti-infective treatment is one of the most important treatment measures for serious infections, as it prevents the transition from pre-sepsis to sepsis and prevents direct death from infection.However, the current criterion, Sepsis-3, does not fully meet the definition of sepsis, and is not suitable for outpatient patients, so it is urgent to explore other ways to assist in early screening of sepsis. Starting from the pathophysiological mechanism of sepsis, this article summarizes the research progress on lymphocyte and cytokines for sepsis, and found that lymphocyte, IL-10 and IL-6 may be used as a joint indicator to diagnose sepsis and the prognosis so as to improve the prognosis of sepsis.
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Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy [J]. Nat Rev Immunol, 2013, 13(12):862-874.
Copaescu A, Smibert O, Gibson A, et al. The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection [J]. J Allergy Clin Immunol, 2020, 146(3):518-534.e511.
Kang S, Tanaka T, Inoue H, et al. IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome [J]. Proc Natl Acad Sci U S A, 2020, 117(36):22351-22356.
Song J, Park DW, Moon S, et al. Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions [J]. BMC Infect Dis, 2019, 19(1):968.
Yang KD, He Y, Xiao S, et al. Identification of progranulin as a novel diagnostic biomarker for early-onset sepsis in neonates [J]. Eur J Clin Microbiol Infect Dis, 2020, 39(12):2405-2414.
Celik IH, Demirel FG, Uras N, et al. What are the cut-off levels for IL-6 and CRP in neonatal sepsis? [J]. J Clin Lab Anal, 2010, 24(6):407-412.
Leech JM, Lacey KA, Mulcahy ME, et al. IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections [J]. J Immunol, 2017, 198(6):2352-2365.
Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells [J]. Nat Rev Immunol, 2010, 10(3):170-181.
Marchant A, Devière J, Byl B, et al. Interleukin-10 production during septicaemia [J]. Lancet, 1994, 343(8899):707-708.
Potjo M, Theron AJ, Cockeran R, et al. Interleukin-10 and interleukin-1 receptor antagonist distinguish between patients with sepsis and the systemic inflammatory response syndrome (SIRS) [J]. Cytokine, 2019, 120:227-233.
Wang Q, Peng G, Gan L, et al. The Value of Interleukin-10 in the Early Diagnosis of Neonatal Sepsis: A Meta-Analysis [J]. Pediatr Crit Care Med, 2021, 22(9): e492- e501.
Doerflinger M, Haeusler GM, Li-Wai-Suen CSN, et al. Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia [J]. Front Immunol, 2021, 12:641879.
Umakoshi K, Choudhury ME, Nishioka R, et al. B lymphocytopenia and Bregs in a not-to-die murine sepsis model [J]. Biochem Biophys Res Commun, 2020, 523(1): 202-207.
Yoo JR, Kim TJ, Heo ST, et al. IL-6 and IL-10 Levels, Rather Than Viral Load and Neutralizing Antibody Titers, Determine the Fate of Patients With Severe Fever With Thrombocytopenia Syndrome Virus Infection in South Korea [J]. Front Immunol, 2021, 12:711847.
Karabacak P, Toğay VA, Aşcı Çelik D. Lymphocyte DNA damage in sepsis and septic-shock intensive-care patients: Damage is greater in non-intubated patients [J]. Mutat Res Genet Toxicol Environ Mutagen, 2022, 879-880:503516.
Girardot T, Rimmele T, Venet F, et al. Apoptosis-induced lymphopenia in sepsis and other severe injuries [J]. Apoptosis, 2017, 22(2):295-305.
Jiang J, Du H, Su Y, et al. Nonviral infection-related lymphocytopenia for the prediction of adult sepsis and its persistence indicates a higher mortality [J]. Medicine, 2019, 98(29): e16535.
DOI: http://dx.doi.org/10.18686/jn.v12i1.243
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