HPV Testing Can Be Used as a Primary Screening Method for Cervical Lesions Among Women in Western China
Abstract
Objective: The purpose of our study is to explore screening strategies suitable for cervical cancer and precancerous lesions in Western Chinese women. Methods: Between January 2010 and December 2020, a total of 7009 patients were diagnosed with high-grade squamous intraepithelial neoplasia (CIN2+) after HPV testing, cytology screening or a combination of both. Results: The positive rate of human papillomavirus (HPV) was 91.2% and the cytology was 75.1%. The negative rate of co-testing was 2%. 2453 (45.2%) cases were infection with HPV16, following HPV58 (1131, 20.8%), HPV52 (1043, 19.2%), HPV33 (566, 10.4%), HPV18 (294, 5.4%). HPV16/18-positive and cytology-negative infection rate was 54.5%, HPV52/58/33-positive and cytology-negative infection rate was 44.7%, the difference was 9.8%. 35-45 years old is the peak age for the incidence of CIN2+ patients. Conclusion: The common genotypes of HPV infection are HPV16, 58, 52, 33 and 18. Cytology negative patients with HPV52/58/33 positive are recommended to be referred for colposcopy as soon as possible. HPV testing is the primary method of cervical cancer or cervical lesions screening among women in western China, and HPV testing is more sensitive than cytology in predicting cervical lesions.
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DOI: http://dx.doi.org/10.18686/jn.v12i1.255
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