Qualitative Study on Nutrition and Immune-Mediated Adverse Events in Patients with Hepatocellular Carcinoma Immunotherapy in Hainan Province

Abstract

Objective To gain an in-depth understanding of the nutritional and immune adverse event perceptions and needs of immunotherapy patients with hepatocellular carcinomain Hainan province, with the aim of providing a basis for developing a model for thefull management of adverse event symptoms and nutrition in immunotherapy patients with hepatocellular carcinoma. Methods Using the phenomenological research method in qualitative research, 13 immunotherapy patients with hepatocellular carcinoma were interviewed in depth in asemi-structured manner, and the interview data were analyzed by the Colaizzi's 7-stepmethod on phenomenological data with the Nvivo10 software. Result Four themes were summarized: multiple factors to undernutrition; adverse event of immune; ignorance the correlation of immune adverse event and nurtrition; the way to acquiring nutrition and immune adverse event was diverse; timely, professional data-based and continuous guidance was needed. Conclusion Despite the adverse event of immunotherapy patients with hepatocellular carcinoma, we should pay attention to the nutritional needs and the treatment of adverse immune events in physiological, social, psychological and environmental asperc, to achieve a multi-form educational intervention mode with self-management and establish a feasible high-quality, efficient and sustainable whole-course management mode.