Clinicopathological Analysis of 4 Cases of Juvenile Ovarian Mucinous Tumor

Abstract

Objective To investigate the clinicopathological features, immunophenotype, diagnosis and differential diagnosis of juvenile ovarian mucinous tumors. Methods The clinical data, pathological features and immunophenotypes of 4 cases of ovarian mucinous tumors were analyzed retrospectively, and the related literature was reviewed. Results The 4 patients were aged 13-17 years, with an average age of 15 years. The main clinical manifestations were abdominal pain or distension. The maximum tumor diameter was 5-27cm, with an average of 16cm. All tumors were unilateral, 2 cases were left side, 2 cases were right side, 2 cases were benign and 2 cases were malignant. The benign is cystic, the malignant is cystic solid, the inner wall of the capsule can be seen papillary neoplasm and contain thick liquid. Microscopically, the tumor was composed of mucinous epithelium and clear cell grip. It was dominated by complex papillae with adenoid, cribriform or solid structure. Immunophenotype: CK7, CDX2, CEA, PCK, Her2, P16, the Ki67, P53, MSH6, MLH1, MSH2, PMS2, CK20 of tumor cells were positive, PAX8, ER, PR positive, PAS staining were positive. TNM/FIGO staging :IA case, 1 case, IC case. Follow-up 1-12 months, all patients tumor free survival. Conclusion The juvenile ovarian mucinous tumor has its unique clinicopathological features and needs to be differentiated from other epithelial ovarian tumors.