Analysis of the Clinical Effect of Nifedipine Combined with Labetalol in the Treatment of Hypertension during Pregnancy

Abstract

Objectives: To investigate the role of labetalol in combination with nifedipine in patients with hypertension during pregnancy. Methods: A total of 120 pregnant women who underwent prenatal care and terminated pregnancy in our hospital were selected as the study subjects, and they were divided into two groups, 60 in each group, in which the control group was given nifedipine monotherapy orally to control blood pressure, and the experimental group was given nifedipine combined with labetalol to control blood pressure. Both groups were administered orally. The blood pressure, blood viscosity, hematocrit, and 24-hour urine protein content of the two groups were measured. Data on maternal delivery methods, delivery outcomes, fetal outcomes, complications, etc. were collected and compared and analyzed.  Both groups had different degrees of systolic and diastolic blood pressure reduction after medication, and there were significant differences compared with the control group (P<0.05). The blood viscosity, hematocrit and 24-hour urine protein content of patients in the experimental group were significantly different from those in the control group (P<0.05); The rate of cesarean section, preterm birth and postpartum hemorrhage in the experimental group was significantly reduced (P<0.05). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group (P<0.05), and none of them had perinatal death. Nifedipine combined with labetalol has a good therapeutic effect in patients with hypertension during pregnancy.