Journal of Nursing

To Explore the Pathogenesis and Treatment Progress of Post_x0002_Stroke Depression Based on the Microbe-Gut-Brain Axis

Jun Yin

Abstract


Post-stroke depression and Post-stroke depression (PSD) has seriously affected the cognitive recovery, neurological rehabilitation,
and the improvement of life quality in patients after stroke. In recent years, many studies found that the regulation of microbial-gut-brain
axis can provide new ideas for treatment, intestinal flora is a key factor to regulate the brain gut axis signal pathway, through the PSD pathogenesis regulate brain neurons, endocrine system, metabolism and immune system pathway, keep the two-way communication between the
brain and gut, alleviate depression behavior. The stroke-depression-stroke relationship proves that stroke can further develop depression, and
depression can increase the risk of stroke recurrence and death. Most patients with PSD have poor compliance to traditional antidepressants
and urgently need to explore more effective treatments. Based on the understanding of intestinal flora, this paper is based on the influence of
intestinal flora changes and PSD in the brain-gut axis. The aim is to explore the potential relationship between the pathogenesis of stroke depression and the brain-gut mechanism, and to provide new ideas and reference for the diagnosis and treatment of PSD.

Keywords


Post-Stroke Depression; Microbe-Gut-Brain Axis; Pathogenesis; Intestinal Microflora

Full Text:

PDF

Included Database


References


[1] Frank D, Gruenbaum BF, et al. Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review.Int J Mol

Sci.2022 Dec 1;23(23):15114.

[2] Guo J, Wang J, Sun W, Liu X. The advances of post-stroke depression: 2021 update.J Neurol. 2022 Mar;269(3):1236-1249.

[3] Riehl L, F├╝rst J, Kress M, Rykalo N.The importance of the gut microbiome and its signals for a healthy nervous system and the

multifaceted mechanisms of neuropsychiatric disorders.Front Frontiers in Neuroscience.2024 Jan 5;17:1302957.

[4] Wu Yifan, Du Donglin, Sun Xiaochuan. Progress of the microbial-gut-brain axis in neurological diseases [J]. Chongqing Medical,

2022,51 (01): 143-146 + 153.

[5] Liu Lanxiang, Wang Haiyang, Xie Peng. Entergut-brain molecular mechanism of gut microbial disorder-induced depression [J].

Journal of Chongqing Medical University, 2021,46 (09): 1003-1007.

[6] Tan Jing, Han Jiangquan, Hu Chunting, etc. Summary of the best evidence for depression management after stroke [J]. Journal of

Nursing, 2020,27 (23): 42-48.

[7] Wei N, Li C, et al.Fluoxetine regulates the neuronal differentiation of neural stem cells transplanted into rat brains after stroke by

increasing the 5HT level.Neurosci Lett.2022 Feb 16;772:136447.

[8] Mitazaki S, Nakagawasai O, et al.Role of prefrontal cortical 5-HT 2A receptors and serotonin transporter in the behavioral deficits

in post-pubertal rats following neonatal lesion of the ventral hippocampus.Behav Brain Res.2020 Jan 13;377:112226.

[9] Liu Lin, Yuan Xiahong, Yi Yaqiao, etc. Experimental study of regulating the inflammatory response of the depressed brain-gut axis

after stroke via P2X7R / NLRP 3 [J]. Shizhen National Medicine, 2022,33 (05): 1051-1055.

[10] Liu Yuanyue, Hu Dan, Ding Caixia and so on. Effect of bupleurum plus keel oyster soup on microglial polarization and synaptic

plasticity in post-stroke depressed rats [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2023,39 (08): 746-752.

[11] Li Yahuan, Liang Xingchen, Jiang Huili, etc. SP600125 Effect of blocking JNK signaling on the HPA axis in rats with chronic unpredictability and mild stress [J]. Clinical Journal of Acupuncture, 2019,35 (09): 62-67.

[12] Jiang Guangxiang, Liu Yixing, Han Dongran. Network analysis of TCM constitution and psychological symptoms [J]. Journal of

Chongqing Medical University, 2023,48 (12): 1401-1407.

[13] Ouyang Xinyi. Based on the brain-gut axis theory, the clinical effect of treating constipation after stroke and its effect on related

brain-gut peptide levels were observed [D]. Hunan University of Traditional Chinese Medicine, 2023.

[14] Wang Wenjing. FBXL20 The mechanism of regulating synaptic plasticity to promote the pathogenesis of depression [D]. Shan_x0002_dong University, 2023.

[15] Chen Yan, Ju Xinmei, Cao Feifei and so on. Hippocampal miR-98-5p participates in depression by regulating brain-derived neurotrophic factors [J]. Journal of Xuzhou Medical University, 2023,43 (12): 874-881.

[16] Liu Jinfeng, Cui Haidong, Han Xinhui, etc. Based on CiteSpace and VOSviewer visual analysis of the research hotspots and

trends of intestinal flora in the field of TCM in the past 30 years [J]. Chinese Journal of Microecology, 2023,35 (07): 756-764.

[17] Hao Dandan, Shen Dan, Fu Fuhua and so on. Progress in the antidepressant effects of flavonoids based on the microbe-gut-brain

axis [J]. Food Science, 2023,10 (10): 1-15.

[18] Medeiros GC, Roy D, Kontos N, Beach SR.Post-stroke depression: A 2020 updated review.Gen Hosp Psychiatry.2020 SepOct;66:70-80.

[19] Xin Yongfei, Ais, Wei Haijing, etc. Correlation between serum 5-HT, Obestatin, and APRIL and neurological function in elderly

stroke patients and their predictive value in post-stroke depression [J]. Advances in Modern biomedicine, 2023,23 (22): 4309-4314.

[20] Thing M, Werge MP, Kimer N, et al.Targeted metabolomics reveals plasma short-chain fatty acids are associated with metabolic

dysfunction-associated steatotic liver disease.BMC Gastroenterol.2024 Jan 23;24(1):43.

[21] Zhuang W, Liu S L, Xi S Y, et al .Traditional Chinese medicine decoctions and Chinese patent medicines for the treatment of depression: Efficacies and mechanisms [J]. J Ethnopharmacol, 2023, 307: 116272.

[22] Huang Qian, Dai Guoliang, Yang Xinyi, et al. UHPLC-TOF-MS combined with network pharmacology and experimental validation to study the mechanism of Jiaotai pill in the treatment of depression [J]. Chinese Journal of Traditional Chinese Medicine, 2024,1 (27),

1-11.

[23] Bear forest. Study on the mechanism of regulating total intestinal microflora / functional microbiota producing SCFAs to improve

depression-like behavior in CUMS rats [D]. Jiangxi University of Traditional Chinese Medicine, 2022.

[24] Ma C, Yuan D, Renaud S J, et al.Chaihu-Shugan-San alleviates depression-like behavior in mice exposed to chronic unpredictable

stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA [J].Front Pharmacol, 2022, 13: 1040591.

[25] Zou Renying, Zhu Huiyue, Xu Mengshu, et al. Relief and mechanism of chronic stress-induced depression and constipation [J].

Food and Fermentation Industry, 2021,47 (03): 1-9.




DOI: http://dx.doi.org/10.18686/nursing.v13i1.327

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Jun Yin