Journal of Nursing

To Explore the Pathogenesis and Treatment Progress of Post_x0002_Stroke Depression Based on the Microbe-Gut-Brain Axis

Jun Yin


Post-stroke depression and Post-stroke depression (PSD) has seriously affected the cognitive recovery, neurological rehabilitation,
and the improvement of life quality in patients after stroke. In recent years, many studies found that the regulation of microbial-gut-brain
axis can provide new ideas for treatment, intestinal flora is a key factor to regulate the brain gut axis signal pathway, through the PSD pathogenesis regulate brain neurons, endocrine system, metabolism and immune system pathway, keep the two-way communication between the
brain and gut, alleviate depression behavior. The stroke-depression-stroke relationship proves that stroke can further develop depression, and
depression can increase the risk of stroke recurrence and death. Most patients with PSD have poor compliance to traditional antidepressants
and urgently need to explore more effective treatments. Based on the understanding of intestinal flora, this paper is based on the influence of
intestinal flora changes and PSD in the brain-gut axis. The aim is to explore the potential relationship between the pathogenesis of stroke depression and the brain-gut mechanism, and to provide new ideas and reference for the diagnosis and treatment of PSD.


Post-Stroke Depression; Microbe-Gut-Brain Axis; Pathogenesis; Intestinal Microflora

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