Effect on Postpartum Hemorrhage of Prophylactic Oxytocin

Abstract

Objective: To analyze the effects of postpartum prophylactic use of oxytocin on reducing the incidence of postpartum hemorrhage. Methods: 220 cases of maternal patients admitted in our hospital from December 2015 to December 2016 were selected as the subjects. According to the random number table method, the control group and the observation group were divided into 110 cases respectively. Control group was given intravenous injection of 20U oxytocin after fetal delivery to prevent postpartum hemorrhage; observation group was given intravenous injection of combination oxytocin and misoprostol for prevention of postpartum hemorrhage. The levels of serum calcium, D-dimer, fibrin (FIB), postpartum hemorrhage at 2, 24 hours and the duration of the third stage of labor were compared between the two groups. The adverse reactions and complications of the two groups were compared, to evaluate the efficacy and safety of misoprostol combined with oxytocin to prevent postpartum hemorrhage. Results: There was no significant difference in blood calcium level between the two groups after delivery (P> 0.05). The D-dimer in the observation group was lower than that in the control group, the FIB level of observation group was also higher than that of the control group, and the difference was significant (P <0.05). Postpartum hemorrhage at 2, 24 hours in the observation group was lower than that in the control group (P <0.05), and the third stage of labor in the observation group was shorter than that in the control group (P <0.05). After treatment, two groups of maternal showed less adverse reactions, and mild symptoms of adverse reactions, no complications, the difference between groups was not statistically significant (P> 0.05). Conclusion: Oxytocin combined with misoprostol can reduce maternal postpartum hemorrhage, worthy of clinical promotion.